House waited a moment, and then shook his head. "He's not good."

It wasn't even just the physical symptoms, though the muscle weakness had gotten worse. He was just starting to have trouble with his bowels and bladder, and that was what really set things off. James didn't want House to help him, and when he felt helpless and embarrassed he could get antagonistic... Though House was also starting to wonder if the mood swings were also a symptom.